Effect of Vitamin D Supplementation in Systemic Hypertension in Tertiary Care Teaching Hospital, Navi-Mumbai

Introduction: There is a growing body of evidence that shows a link between hypertension and vitamin D deficiency. Vitamin D is said to have several pleiotropic actions, including a strong influence on cardiovascular system. Blood pressure (BP), lipid profile, glycemic pattern, inflammatory state and cardiometabolic risk are inversely associated with plasma vitamin D values. Studies suggest that low vitamin D levels are associated with a higher risk of hypertension but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). Material and methods: The study was conducted in the tertiary care teaching hospital, in outpatient Department of General Medicine in 104, hypertensive subjects with vitamin D deficiency. The patients received both antihypertensive as well as Vitamin D supplementation i.e. Vitamin D3 60,000 IU once a week for 6 week in the morning. Results: The present study noted a statistically significant fall in systolic blood pressure in group 2 from 142.6± 1.92 to 139.1 ± 2.1*(p<0.05). Group 2 patients showed an insignificant fall in diastolic blood pressure from 82.5± 2.6 to 81.0 ± 2.9. Conclusion: From the above study it is clear that Vitamin D supplementation has a role in the regulation of blood pressure. Dr. Vaishali Thakare*, Dr. P. Yadav, Dr. Lily Dubey Dr. D. Y. Patil Medical College, Nerul, Navi-Mumbai Submission: 5 July 2017 Accepted: 12 July 2017 Published: 25 July 2017 www.ijppr.humanjournals.com Citation: Dr. Vaishali Thakare et al. Ijppr.Human, 2017; Vol. 9 (4): 71-79. 72 INTRODUCTION Hypertension, also known as high blood pressure, is a major modifiable risk factor for heart disease and stroke. Elevated blood pressure is an independent risk factor for coronary heart disease, stroke, congestive heart failure, and chronic renal disease. It is associated with high mortality rate, accounting for an estimated 14% of cardiovascular deaths worldwide and 18% of deaths in high income countries (Vitamin D and hypertension). However, despite advances in medical treatment and public campaigns to reduce the prevalence of hypertension, the disease remains a significant cause of health problems with huge health impacts mainly due to limited knowledge of risk factors related to the condition. Hypertension has many etiological factors, which include age, race, family history, obesity, sedentary lifestyle, using tobacco, high salt intake, stress, and consumption of alcohol in a larger quantity (1). Interestingly, there is a growing body of evidence that shows a link between hypertension and vitamin D deficiency. Vitamin D is known for its role on the bone and calcium-phosphorus metabolism, but in the last years, a rising number of observations have highlighted several pleiotropic actions, including a strong influence on cardiovascular system (2,3). Blood pressure (BP), lipid profile, glycemic pattern, inflammatory state and cardio-metabolic risk are inversely associated with plasma vitamin D values (4-10). Observational studies suggest that low vitamin D levels are associated with a higher risk of hypertension but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). If vitamin D supplementation lowers blood pressure, its widespread use could have major public health benefits. Hence we aim to evaluate whether vitamin D supplementation is effective to reduce blood pressure in hypertensive patients. Aims and objectives To study the effect of Vitamin D3 Supplementation on Blood pressure in Hypertensive subjects. MATERIAL AND METHODOLOGY The study was conducted in the tertiary care teaching hospital, in outpatient Department of General Medicine. www.ijppr.humanjournals.com Citation: Dr. Vaishali Thakare et al. Ijppr.Human, 2017; Vol. 9 (4): 71-79. 73 Study period – This study was conducted from for a period of 1 year, after getting clearance from the Institutional ethics committee. Sample size – 104 hypertensive subjects with vitamin D deficiency were enrolled in the study after taking an informed consent.